SPECIFIC POSITIVE SELECTION OF LYMPHOCYTES REACTIVE TO STRONG HISTOCOMPATIBILITY ANTIGENS
نویسندگان
چکیده
منابع مشابه
Specific Positive Selection of Lymphocytes Reactive to Strong Histocompatibility Antigens
Selected populations of thymus-derived (T) rat lymphocytes having specific immunological reactivity to chosen histocompatibility (H) alloantigens are found among the cellular products of the mixed lymphocyte interaction (MLI). Such specific selection seems to depend on (a) the antigen-induced proliferation of specific H antigen reactive cells (HARC), and (b) the disappearance of nonreactive cel...
متن کاملSpecific Positive Selection of Lymphocytes
The population of thymus-derlved (T) lymphocytes reactive to strong histocompatibility (H) 1 alloantigens (HARC) is peculiar in two respects in comparison to lymphocytes~responsive to other antigens: first, the T cells reactive to any given strong H antigen outnumber by two to three orders of magnitude the T cells responsive to more conventional antigens (1-3); and secondly, the frequency of HA...
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We have examined whether the thymus can produce immature T cell precursors for subsequent positive selection in the periphery. Using the intestine as a model system, we demonstrate that extrathymic MHC class I molecules positively select thymus-derived TCR-alpha beta CD8+ intestinal intraepithelial lymphocytes. Grafting of MHC class I+ thymus onto MHC class I- hosts resulted in the generation o...
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Two reciprocal interspecies hybrid class I histocompatibility genes have been constructed between genomic clones of human HLA-A2 and murine H-2Kb. The proteins encoded by these genes have been designated A21+2/Kb, where the polymorphic domains, alpha 1 and alpha 2, of HLA-A2 are linked to the carboxyl-terminal domains (alpha 3, transmembrane, and intracytoplasmic domains) of H-2Kb, and Kb1+2/A2...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1974
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.140.3.660